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Published on: September 25, 2012
Brain tumours in infancy: a clinicopathological study.
S Hanieh1, A Hanieh, A J Bourne
1Department of Histopathology Women's and Children's Hospital, Adelaide, Australia.
Summary
Infants can develop a variety of brain tumors, differing from those in older children. Early diagnosis through antenatal ultrasound may identify congenital intracranial tumors.
Area of Science:
- Pediatric Oncology
- Neuropathology
- Developmental Neuroscience
Background:
- Intracranial neoplasms in infancy present unique challenges.
- Understanding clinicopathological features is crucial for diagnosis and management.
Purpose of the Study:
- To investigate the clinicopathological characteristics of brain tumors diagnosed in infants.
- To differentiate infantile brain tumors from those in older children.
Main Methods:
- Retrospective review of hospital records and histopathology data from 1962 to 1993.
- Analysis of 24 infant cases with intracranial neoplasms.
Main Results:
- A diverse range of brain tumors were identified in 24 infants (age 5 days to 1 year).
- Tumors were predominantly supratentorial (58%) with a male predominance (17:7).
- Congenital malformations may influence tumor location; metastatic malignancy is rare.
Conclusions:
- Infantile brain tumors exhibit distinct clinical presentations and locations compared to older children.
- Antenatal ultrasound may aid in detecting congenital intracranial tumors.
- Further research into specific tumor types and outcomes is warranted.
