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Updated: Jul 3, 2026

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
Published on: November 19, 2012
Traumatic Korsakoff syndrome
1Department of Neurosurgery, Komaki City Hospital, 1-20 Jobushi, Komaki City, Aichi 485, Japan.
Abstract:
A case of Korsakoff's syndrome occurring after a fall is reported. The patient was comatose on admission. Cerebral contusions were seen in the frontal lobes bilaterally, left temporal lobe, right caudate nucleus and cerebellar vermis. Cerebral blood flow (CBF) study showed diffuse hyperaemia. Although his conscious state improved gradually, he showed disorientation, antegrate and retrograde amnesia and confabulation 2.5 months later and was diagnosed as having Korsakoff's syndrome. Magnetic resonance imaging (MRI) and CBF studies during this period showed damage in the midbrain and general hypoperfusion. He recovered gradually, confabulation disappeared but a mild memory disturbance remained; hypoperfusion on CBF studies also improved up to the normal range. Among the limbic diencephalic structures, the frontal lobes were thought to be involved most prominently in this case of Korsakoff syndrome.
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Amnesia
The severity and duration of memory loss vary depending on the type and underlying cause. Amnesia is classified into two main types: retrograde and anterograde.
Retrograde amnesia is marked by the loss of memories formed before the onset of the condition. Patients may recall distant past events but often forget those occurring shortly before the incident.
Anterograde...