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Basic mechanisms of pain associated with deep tissues.

R Dubner1

  • 1Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.

Canadian Journal of Physiology and Pharmacology
|May 1, 1991
PubMed
Summary

Deep tissue pain differs from skin pain due to unique nociceptive systems. This pain can cause long-lasting central nervous system changes, impacting chronic pain conditions and their treatment.

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Area of Science:

  • Neuroscience
  • Pain Research
  • Physiology

Background:

  • Pain perception varies significantly between cutaneous (skin) and deep tissue sources.
  • Deep tissues include muscles, joints, and visceral organs, each with distinct nociceptive pathways.
  • Understanding these differences is crucial for diagnosing and treating pain.

Purpose of the Study:

  • To elucidate the unique characteristics of deep tissue pain compared to cutaneous pain.
  • To explore the role of nociceptive system organization in deep tissue pain.
  • To investigate the potential of deep tissue pain to induce long-term changes in the central nervous system (CNS).

Main Methods:

  • Review of recent evidence on nociceptive systems.
  • Analysis of studies investigating deep tissue stimulation.
  • Examination of research on central nervous system excitability changes.

Main Results:

  • Deep tissue pain involves distinct nociceptive systems compared to skin pain.
  • Stimulation of deep tissues can lead to persistent alterations in CNS excitability.
  • These alterations suggest a significant role in chronic pain development.

Conclusions:

  • Deep tissue pain has unique physiological underpinnings.
  • Chronic deep tissue pain may result from long-lasting neuroplastic changes in the CNS.
  • Current treatment strategies may need to consider these neurophysiological effects for chronic deep tissue pain.

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