Related Experiment Video
Updated: Jul 3, 2026

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
Amnesia after basal forebrain damage due to anterior communicating artery aneurysm rupture
R A Wright1, B F Boeve, J F Malec
1Department of Neurology, Dunedin Public Hospital, Dunedin, New Zealand.
Abstract:
A 53-year-old male presented with a subarachnoid haemorrhage secondary to an anterior communicating artery aneurysm rupture. The aneurysm was successfully treated with intravascular coiling. Post-haemorrhage the patient showed a profound amnestic syndrome with deficits in anterograde (and also retrograde) memory, confabulation and personality changes consistent with the anterior communicating artery syndrome (ACAS). Magnetic resonance imaging showed basal forebrain and orbitofrontal infarction. The patient was treated with donepezil (a cholinesterase inhibitor) without symptomatic improvement or clinically meaningful change in his psychometric testing. The clinical and neuropsychological features and the pathological basis of the ACAS are reviewed.
Related Concept Videos
The Arch of Aorta
Encircling the heart, the coronary arteries form a ring-like structure before...
Amnesia
The severity and duration of memory loss vary depending on the type and underlying cause. Amnesia is classified into two main types: retrograde and anterograde.
Retrograde amnesia is marked by the loss of memories formed before the onset of the condition. Patients may recall distant past events but often forget those occurring shortly before the incident.
Anterograde...
Aneurysm I: Introduction
Olfactory Receptors: Location and Structure
Hemorrhagic Stroke ll: Pathophysiology
Cerebral Edema ll: Pathophysiology

