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Updated: Jul 3, 2026
08:56
Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
Published on: October 7, 2021
Neurolymphomatosis presenting as mononeuritis multiplex
S P Bower1, P McKelvie, R W Peppard
1Department of Clinical Neurosciences, St Vincent's Hospital, Fitzroy, Australia 3065.
Summary
Neurolymphomatosis, a rare lymphoma affecting nerves, was diagnosed posthumously in a 60-year-old man. Early MRI of peripheral nerves may aid antemortem diagnosis of this elusive condition.
Area of Science:
- Neurology
- Oncology
- Pathology
Background:
- Neurolymphomatosis is a rare condition involving lymphoma infiltration of the nervous system.
- It often presents with symptoms mimicking other neurological disorders, leading to diagnostic challenges.
Purpose of the Study:
- To report a case of neurolymphomatosis diagnosed posthumously.
- To highlight the potential diagnostic utility of advanced imaging in similar elusive cases.
Main Methods:
- Case report of a 60-year-old male with progressive neurological deficits.
- Extensive investigations including lumbar punctures and tissue biopsies.
- Postmortem examination to confirm diagnosis.
Main Results:
- The patient presented with mononeuritis multiplex, progressing over 10 months.
- Postmortem examination revealed lymphocytic infiltration of peripheral nerves and radicules, consistent with neurolymphomatosis.
- No systemic lymphoma was found, except for pericardial involvement.
Conclusions:
- Neurolymphomatosis can present without systemic lymphoma and be difficult to diagnose antemortem.
- Magnetic resonance imaging (MRI) of plexi and peripheral nerves may improve early diagnosis.
- Prompt diagnosis is crucial for potential therapeutic intervention.
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