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Related Experiment Video

Updated: Jul 3, 2026

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
08:56

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

Published on: October 7, 2021

Neurolymphomatosis presenting as mononeuritis multiplex.

S P Bower1, P McKelvie, R W Peppard

  • 1Department of Clinical Neurosciences, St Vincent's Hospital, Fitzroy, Australia 3065.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|July 22, 2008
PubMed
Summary

Neurolymphomatosis, a rare lymphoma affecting nerves, was diagnosed posthumously in a 60-year-old man. Early MRI of peripheral nerves may aid antemortem diagnosis of this elusive condition.

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09:41

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Published on: July 19, 2019

Area of Science:

  • Neurology
  • Oncology
  • Pathology

Background:

  • Neurolymphomatosis is a rare condition involving lymphoma infiltration of the nervous system.
  • It often presents with symptoms mimicking other neurological disorders, leading to diagnostic challenges.

Purpose of the Study:

  • To report a case of neurolymphomatosis diagnosed posthumously.
  • To highlight the potential diagnostic utility of advanced imaging in similar elusive cases.

Main Methods:

  • Case report of a 60-year-old male with progressive neurological deficits.
  • Extensive investigations including lumbar punctures and tissue biopsies.
  • Postmortem examination to confirm diagnosis.

Main Results:

  • The patient presented with mononeuritis multiplex, progressing over 10 months.
  • Postmortem examination revealed lymphocytic infiltration of peripheral nerves and radicules, consistent with neurolymphomatosis.
  • No systemic lymphoma was found, except for pericardial involvement.

Conclusions:

  • Neurolymphomatosis can present without systemic lymphoma and be difficult to diagnose antemortem.
  • Magnetic resonance imaging (MRI) of plexi and peripheral nerves may improve early diagnosis.
  • Prompt diagnosis is crucial for potential therapeutic intervention.