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Lincocinamides and the incidence of antibiotic-associated colitis
1Center for Research on Infectious Diseases, Institute of Public Health, Cuernavaca, Morelos, Mexico.
Abstract:
Reports of antibiotic-associated colitis (AAC) and of pseudomembranous colitis in patients treated with lincocinamides and other antimicrobial agents are reviewed. It is apparent that the incidence of colitis in patients treated with antimicrobials is declining. The greatest risk for AAC is seen in patients treated with ampicillin, followed by the cephalosporins, and then the lincocinamides. Treatment of AAC with vancomycin, metronidazole, or bacitracin is usually effective.
Insights
Antibiotic-associated colitis (AAC) incidence is decreasing. Ampicillin poses the highest risk, followed by cephalosporins and lincocinamides, but vancomycin, metronidazole, or bacitracin are effective treatments.
Area of Science:
- Microbiology
- Gastroenterology
- Pharmacology
Background:
- Antibiotic-associated colitis (AAC) and pseudomembranous colitis are potential adverse effects of antimicrobial therapy.
- Lincocinamides and other antimicrobial agents have been implicated in causing colitis.
Purpose of the Study:
- To review the incidence and risk factors associated with antibiotic-associated colitis.
- To evaluate the effectiveness of different treatments for antibiotic-associated colitis.
Main Methods:
- Literature review of reported cases of antibiotic-associated colitis.
- Analysis of antimicrobial agents and their association with colitis incidence.
- Review of treatment outcomes for antibiotic-associated colitis.
Main Results:
- The overall incidence of antibiotic-associated colitis appears to be declining.
- Ampicillin presents the highest risk for AAC, followed by cephalosporins, then lincocinamides.
- Vancomycin, metronidazole, and bacitracin demonstrate effectiveness in treating AAC.
Conclusions:
- While the incidence of AAC is decreasing, vigilance is still required.
- Understanding the differential risks of various antibiotics is crucial for prevention.
- Established treatments for AAC are generally effective.