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Related Experiment Video

Updated: Jul 3, 2026

Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish
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Zebrafish as a model for infectious disease and immune function.

Con Sullivan1, Carol H Kim

  • 1Department of Biochemistry, University of Maine, Orono, ME 04469, USA.

Fish & Shellfish Immunology
|July 22, 2008
PubMed
Summary

Zebrafish (Danio rerio) are valuable models for human disease research, including infectious diseases. Their use is expanding to study finfish pathogens, aiding vaccine development for important fish species.

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Area of Science:

  • Biomedical Research
  • Comparative Pathology
  • Aquatic Animal Health

Background:

  • Zebrafish (Danio rerio) are increasingly utilized in biomedical research for human disease modeling.
  • Extensive genetic and genomic data make zebrafish a suitable model for teleost studies.
  • The zebrafish model system offers insights into immunology, toxicology, and neurobiology.

Purpose of the Study:

  • To review the capabilities and potential of zebrafish as a model for infectious disease studies.
  • To present an overview of existing zebrafish infectious disease models.
  • To highlight the relevance of zebrafish research for understanding and combating fish pathogens.

Main Methods:

  • Leveraging the extensive genetic and genomic information available for zebrafish.

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Zebrafish Animal Model for the Study of Allergic Reactions in Response to Tick Saliva Biomolecules
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Zebrafish Animal Model for the Study of Allergic Reactions in Response to Tick Saliva Biomolecules

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Last Updated: Jul 3, 2026

Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish
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Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses
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Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses

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Published on: September 16, 2022

  • Utilizing commercially available gene microarrays and insertional mutants.
  • Employing gene-specific knockdown of translation via morpholino oligonucleotides.

    • Main Results:

    • Zebrafish models have been developed for studying bacterial and viral infections.
    • These models facilitate the investigation of immune responses to pathogens.
    • Research using zebrafish pathogen models can inform human infectious disease research.

    Conclusions:

    • Zebrafish serve as a powerful model for studying finfish pathogens and immune responses.
    • Findings from zebrafish infectious disease models can guide the development of vaccines and treatments for economically important fish.
    • The zebrafish system holds significant potential for advancing aquatic animal health and disease research.