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Callosal lesions and delirious behavior during febrile illness
Akihisa Okumura1, Fumio Hayakawa, Toru Kato
1Department of Pediatrics, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. okumura@med.juntendo.ac.jp
Brain & Development
|July 22, 2008
Summary
Transient callosal lesions are common in children with febrile delirium. This study found no clinical differences between children with or without these brain lesions, suggesting they are not uncommon in this condition.
Area of Science:
- Pediatric Neurology
- Neuroradiology
- Neuroscience
Background:
- Febrile illness in children can lead to delirious behavior.
- The presence and significance of associated neuroimaging findings, such as callosal lesions, require further investigation.
Purpose of the Study:
- To investigate the occurrence and clinical relevance of callosal lesions in children with febrile delirium.
- To compare clinical characteristics and electroencephalography (EEG) findings between children with and without callosal lesions.
Main Methods:
- Retrospective review of electroencephalography (EEG) and magnetic resonance imaging (MRI) data.
- Analysis of 21 children with delirious behavior during febrile illness.
- Comparison of clinical features, delirium characteristics, consciousness levels, and EEG findings.
Main Results:
- Five out of 21 children (23.8%) showed transient callosal lesions on MRI, sometimes with additional white matter lesions.
- No significant differences were observed in clinical characteristics, delirium presentation, or EEG findings between groups with and without callosal lesions.
- Callosal lesions were found to be not uncommon in children with febrile delirium.
Conclusions:
- Transient callosal lesions are a notable finding in pediatric febrile delirium.
- The presence of callosal lesions does not appear to significantly alter the clinical presentation or EEG findings in these children.
- Further research is needed to fully understand the pathogenesis and implications of callosal lesions in febrile delirium.
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