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Published on: July 8, 2025
Usefulness and applicability of femorofemoral crossover bypass grafting
Geertje Thuijls1, L W van Laake, M S Lemson
1Department of Surgery, University Hospital of Maastricht, Maastricht, the Netherlands. g.thuijls@ah.unimaas.nl
Insights
Femorofemoral crossover bypass grafting (FFC) is effective for improving limb status long-term. Preoperative femoral artery stenosis <50% predicts better clinical outcomes, though no factors predict graft patency.
Area of Science:
- Vascular Surgery
- Cardiovascular Medicine
Background:
- Femorofemoral crossover bypass grafting (FFC) is a surgical technique used to treat peripheral artery disease.
- Assessing the long-term efficacy and influencing factors of FFC is crucial for patient management.
Purpose of the Study:
- To evaluate the clinical usefulness and patency rates of femorofemoral crossover bypass grafting (FFC).
- To identify factors influencing the outcomes of FFC procedures.
Main Methods:
- Retrospective analysis of 95 FFC procedures performed over a 5-year period.
- Kaplan-Meier analysis for patency rates (follow-up 40.4 ± 3.0 months).
- Clinical outcome assessment using Rutherford's standardized categories; analysis of cardiovascular risk factors and technical characteristics.
Main Results:
- 89% of patients showed improved limb clinical status post-FFC.
- One- and 5-year primary patency rates were 88.2% and 57.3%; primary assisted 90.6% and 62.4%; secondary 92.6% and 68.1%.
- Better clinical outcomes were observed in patients with preoperative femoral artery stenosis <50% (p=0.033); no predictors for patency were identified.
Conclusions:
- FFC is effective long-term across all age groups, irrespective of cardiovascular risk factors.
- Preoperative degree of stenosis (<50%) is the strongest predictor of favorable clinical outcome.
- Success evaluation requires combining graft patency with clinical outcomes.
Abstract:
We examined the usefulness of femorofemoral crossover bypass grafting (FFC) and factors influencing its outcome by retrospectively analyzing all FFCs performed in our hospital over a 5-year period, focusing on both patency rates and clinical efficacy. For 95 patients Kaplan-Meier patency rates were calculated (follow-up 40.4 +/- 3.0 months). Clinical outcome was defined according to Rutherford's standardized categories. The influence of cardiovascular risk factors and technical characteristics on outcome was determined. Clinical status of the limb remained improved in 89%. One- and 5-year primary, primary assisted, and secondary patency rates were 88.2% and 57.3%, 90.6% and 62.4%, and 92.6% and 68.1%, respectively. Clinical outcome of the limb was better in patients with <50% stenosis in the femoral arteries preoperatively (p = 0.033). No predictors for patency rates were identified. FFCs are effective in the medium long term for patients in all age categories independently of cardiovascular risk factors. The best predictor of clinical outcome is the preoperative degree of stenosis, with a better outcome for patients affected by <50% stenosis. Success of FFC cannot be reliably measured by graft patency alone but should be assessed by combining patency rates and clinical outcome according to standardized categories.
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