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Chronic ocular zoster.

M J Zaal1, P C Maudgal, E Rietveld

  • 1Department of Ophthalmology, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands.

Current Eye Research
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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Systemic acyclovir effectively treated acute herpes zoster ophthalmicus, resolving ocular inflammation quickly. Topical acyclovir was less effective, prolonging symptoms and leading to chronic inflammation in some patients.

Area of Science:

  • Ophthalmology
  • Virology
  • Dermatology

Background:

  • Herpes zoster ophthalmicus (HZO) is a viral infection affecting the eye.
  • Treatment options for HZO include systemic and topical antiviral medications.

Observation:

  • A prospective open trial compared systemic acyclovir with topical acyclovir for acute HZO.
  • Some patients receiving topical treatment also received dexamethasone eye-drops for inflammation.

Findings:

  • Systemic acyclovir led to rapid and complete resolution of ocular inflammation in all patients.
  • Topical acyclovir therapy prolonged new skin lesion formation and ocular inflammatory signs.
  • Chronic ocular inflammation developed in 40% of patients treated with topical acyclovir.

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Implications:

  • Systemic acyclovir is a superior treatment for acute herpes zoster ophthalmicus.
  • Chronic ocular zoster may represent a distinct clinical entity linked to local immune response failure against Varicella-Zoster Virus (VZV).
  • Further research into immune responses in HZO is warranted.