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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...

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Related Experiment Video

Updated: Jul 3, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

Obesity and asthma: a specific phenotype?

Andréa Lessard1, Hélène Turcotte1, Yvon Cormier1

  • 1Centre de Recherche, Hôpital Laval, Institut de cardiologie et de pneumologie de l'Université Laval, Québec, QC, Canada.

Chest
|July 22, 2008
PubMed
Summary
This summary is machine-generated.

Obese individuals with asthma exhibit poorer control and distinct lung function changes compared to non-obese asthmatics, suggesting a unique asthma phenotype. This highlights the need for tailored management strategies for obesity and asthma. Keywords: obesity, asthma, phenotype, lung function.

Related Experiment Videos

Last Updated: Jul 3, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

Area of Science:

  • Pulmonology
  • Allergy and Immunology
  • Obesity Medicine

Background:

  • Obesity is linked to increased asthma prevalence and severity, particularly in women.
  • Asthma control is often poorer in obese individuals.
  • This study investigates a specific asthma phenotype in obese subjects.

Purpose of the Study:

  • To determine if obese subjects with asthma exhibit a distinct asthma phenotype.
  • To compare asthma control, pulmonary function, and inflammatory markers between obese and non-obese asthmatics.

Main Methods:

  • Compared 44 obese (BMI ≥ 30 kg/m²) and 44 non-obese (BMI < 25 kg/m²) asthmatic subjects.
  • Assessed asthma control, methacholine responsiveness, symptom perception, sputum eosinophils/neutrophils, and systemic inflammation markers (CRP, fibrinogen).
  • Measured lung volumes including total lung capacity (TLC), expiratory reserve volume (ERV), functional residual capacity (FRC), and residual volume (RV).

Main Results:

  • Obese asthmatics had poorer asthma control (p=0.005) despite similar symptom perception and airway responsiveness.
  • Obese subjects showed reduced lung volumes: lower TLC (p=0.01), ERV (p<0.0001), FRC (p<0.0001), and RV (p=0.006).
  • Elevated serum C-reactive protein (p=0.009) and fibrinogen (p=0.0004) were observed in obese subjects.

Conclusions:

  • Obese individuals with asthma present with poorer control and a distinct pattern of pulmonary function changes.
  • Inflammatory markers suggest both bronchial and systemic inflammation contribute to this phenotype.
  • Findings indicate a specific asthma phenotype in obese subjects requiring tailored therapeutic approaches.