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Updated: Jul 3, 2026

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
Can tumor growth be further inhibited by combining drugs such as bortezomib with image-guided interventional
1Department of Radiology, Beth Israel Deaconess Medical Center, 1 Deaconess Rd, Room CC308, Boston, MA 02215, USA. sgoldber@bidmc.harvard.edu
Abstract:
Poff et al (1) were able to demonstrate delayed tumor growth of murine squamous cell carcinoma in an orthotopic C3H murine tumor model when adding pulsed high-intensity focused ultrasound (HIFU) as an adjunctive pretreatment to bortezomib, a proteasome inhibitor. In essence, this combination therapy induced greater apoptosis than did the drug alone and enabled the achievement of equivalent efficacy with a substantial dose reduction of a potentially toxic drug.
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