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Related Concept Videos

Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview

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Updated: Jul 3, 2026

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

Serpins in T cell immunity.

Michael Bots1, Jan Paul Medema

  • 1Laboratory of Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands. michael.bots@petermac.org

Journal of Leukocyte Biology
|July 22, 2008
PubMed
Summary
This summary is machine-generated.

Ovalbumin (ov)-serpins are intracellular proteins regulating immune responses. This review explores their specific inhibitory mechanisms and function within immune cells.

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Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
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Last Updated: Jul 3, 2026

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

Area of Science:

  • Biochemistry
  • Immunology

Background:

  • Serine protease inhibitors (serpins) regulate biological processes by inhibiting serine proteases.
  • Serpins utilize a unique conformational change mechanism for protease inhibition.
  • Ovalbumin (ov)-serpins, a distinct subgroup, function intracellularly due to lacking secretion signals.

Purpose of the Study:

  • To review the role of ov-serpins in the immune system.
  • To highlight the intracellular functions and immune regulatory roles of ov-serpins.

Main Methods:

  • Literature review focusing on ov-serpins.
  • Analysis of serpin structure-function relationships.
  • Examination of ov-serpin expression in immune cells.

Main Results:

  • Ov-serpins are expressed in various immune cells.
  • Their expression is tightly regulated, suggesting immune involvement.
  • Ov-serpins play a role in regulating immune responses.

Conclusions:

  • Ov-serpins are key intracellular regulators within the immune system.
  • Understanding ov-serpin function is crucial for immune response modulation.