Related Experiment Video
Updated: Jul 3, 2026

A Microfluidic Approach for the Study of Ice and Clathrate Hydrate Crystallization
Published on: August 18, 2022
Pressure-freezing with conformational conversion of 3-aminopropan-1-ol molecules
Roman Gajda1, Andrzej Katrusiak
1Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznań, Poland.
Abstract:
3-Aminopropan-1-ol, NH(2)(CH(2))(3)OH, was pressure-frozen and its structure determined at 0.2, 0.9 and 1.31 GPa by single-crystal X-ray diffraction. The freezing pressure of 0.13 GPa at 296 K was measured by ruby fluorescence in the diamond-anvil cell and from compressibility measurement in the piston-and-cylinder reaction press. The molecules assume an extended conformation in the crystalline state, different from the pseudo-ring conformers, with the terminal groups linked by an intramolecular hydrogen bond, present in the gaseous and liquid states. The polar arrangement in the 3-aminopropan-1-ol crystals is explained in terms of the pattern of intermolecular hydrogen bonds.
Related Concept Videos
Conformations of Ethane and Propane
Staggered conformation is a low energy and more stable conformation with the C-H bonds on the front carbon placed at 60°dihedral angles relative to the C-H bonds on the back carbon, leading to a reduced torsional strain. In staggered ethane, the...
Conformations of Butane
Conformations of Cycloalkanes
Phase Transitions: Melting and Freezing
¹H NMR of Conformationally Flexible Molecules: Temporal Resolution
¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR

