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Undulating membraneous structures associated with the endoplasmic reticulum in tumour cells
International Journal of Cancer
|November 15, 1976
Summary
Tubuloreticular and undulating membraneous structures (TRS and UMS) are similar cytoplasmic inclusions with different organizations. Their occurrence was studied in normal and cancerous cells, including lung carcinoma and virus-induced chicken liver tumors.
Area of Science:
- Cell Biology
- Pathology
- Electron Microscopy
Background:
- Tubuloreticular structures (TRS) and undulating membraneous structures (UMS) are observed in various cell types.
- Their precise nature and relationship to cellular pathology require further elucidation.
Purpose of the Study:
- To investigate the morphology and occurrence of TRS and UMS.
- To compare these structures under normal and pathological conditions.
- To describe UMS in specific cancer cell lines.
Main Methods:
- Electron microscopy was used to examine cellular structures.
- Comparative analysis of TRS and UMS in different cell types and conditions.
Main Results:
- TRS and UMS were identified as distinct but related cytoplasmic inclusions.
- Differences in organization were noted between TRS and UMS.
- UMS were found in a human lung carcinoma cell line and a chicken hepatoma.
Conclusions:
- TRS and UMS represent similar types of cytoplasmic inclusions with varying organizational patterns.
- The presence of UMS in specific tumor types provides insights into their pathological relevance.