[Influence of hemoultrafiltration and hemodialysis on endothelin]

In order to study the mechanism of plasma ET increment in CRF patients, we investigated 20 endothelin (CRF) patients undergone hemoultrafiltration for 90 min followed by hemodialysis, and 12 patients subjected to single hemodialysis. The results revealed that 90 min's ultrafiltration along with 2500 ml fluid extraction brought about a significant decrease in plasma ET (from 1132 to 753 pg/ml, P less than 0.05), while the hemodialysis without water extraction of a same period resulted no significant change. In the meantime, the BUN in the ultrafiltration group showed no prominent change. But the hemodialysis group presented a significant decrease (from 34.6 to 22.5 mmol/L P less than 0.05), which showed that the ET falling had no significant relevance to the metabolic products extraction. In the followed 120 min's hemodialysis, ET level in the two groups decreased in a different extend. Therefore, the research suggested that decreased extracellular volume via ultrafiltration can lead to the discretion of ET level.