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Updated: Jul 3, 2026
Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
Published on: March 7, 2022
Rosiglitazone-enriched diet did not protect liver ischemia-reperfusion injury in a rat model
Antonio Roberto Franchi Teixeira1, Nilza Trindade Molan, Marta Bellodi-Privato
1Transplantation Division, Department of Gastroenterology, School of Medicine, USP, São Paulo, Brazil. drrteixeira@uol.com.br
Purpose:
To determine whether rosiglitazone-enriched diet offer protection in a classical model of liver ischemia-reperfusion injury in rats.
Methods:
Two days before the experiment, rats were divided into 2 groups: Control Group (n=13) rats fed with standard diet; Rosi Group (n=13): rats fed with a powdered standard diet supplemented with rosiglitazone. The animals were submitted to liver ischemia-reperfusion by clamping the pedicle of median and left anterolateral lobes. After 1 hour of partial hepatic ischemia, the clamp was removed for reperfusion. After 2 or 24 hours (Control and Rosi Groups), blood was collected for enzymes and cytokines analysis. Ischemic and non-ischemic liver were collected for malondialdehyde analysis and histological assessment. Lungs were removed for tissue myeloperoxidase quantification.
Results:
There were no statistical differences between groups for all analysed parameters.
Conclusion:
In this model, rosiglitazone-enriched diet did not protect liver against ischemia-reperfusion injury.
