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Related Experiment Video

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Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
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Microstimulation of monkey dorsolateral prefrontal cortex impairs antisaccade performance.

Stephen P Wegener1, Kevin Johnston, Stefan Everling

  • 1Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada.

Experimental Brain Research
|July 22, 2008
PubMed
Summary

Electrical stimulation of the dorsolateral prefrontal cortex (DLPFC) in monkeys impaired performance on the antisaccade task. This suggests the DLPFC plays a causal role in controlling eye movements and suppressing unwanted responses.

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Primate Research

Background:

  • The dorsolateral prefrontal cortex (DLPFC) is recognized for its role in cognitive functions, notably response suppression.
  • The antisaccade task is a standard method for assessing response suppression, requiring participants to inhibit a reflexive prosaccade and execute a voluntary antisaccade.

Purpose of the Study:

  • To investigate the causal relationship between dorsolateral prefrontal cortex (DLPFC) activity and antisaccade task performance.
  • To determine if electrical microstimulation of the DLPFC directly influences saccadic eye movement control.

Main Methods:

  • Electrical microstimulation was applied to specific sites within the DLPFC of two monkeys.
  • Monkeys performed a task with randomly interleaved prosaccade and antisaccade trials during stimulation.

Main Results:

  • Microstimulation led to significantly increased reaction times for ipsilaterally directed prosaccades and antisaccades.
  • An elevated error rate was observed specifically for ipsilateral antisaccade trials following microstimulation.

Conclusions:

  • The findings provide causal evidence linking dorsolateral prefrontal cortex (DLPFC) activity to the control of saccadic eye movements.
  • Activity within the DLPFC appears to modulate both the speed and accuracy of visually guided eye movements, particularly during response inhibition.