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Published on: August 28, 2018
Prevalence and morphology of coronary artery ectasia with dual-source CT coronary angiography
Sebastian Leschka1, Paul Stolzmann, Hans Scheffel
1Institute of Diagnostic Radiology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.
Insights
Coronary artery ectasia (CAE) prevalence is approximately 3% when assessed by CT coronary angiography (CTCA). CTCA measurements of CAE diameter and contrast attenuation correlate well with conventional catheterangiography (CCA) findings and flow alterations.
Area of Science:
- Cardiovascular Imaging
- Radiology
- Interventional Cardiology
Background:
- Coronary artery ectasia (CAE) is a dilation of coronary arteries.
- Accurate assessment of CAE prevalence and characteristics is crucial for understanding its clinical implications.
Purpose of the Study:
- To evaluate the prevalence and morphological features of CAE using CT coronary angiography (CTCA).
- To compare CTCA findings with conventional catheterangiography (CCA) for diameter measurements and contrast attenuation.
Main Methods:
- Retrospective analysis of 677 patients undergoing dual-source CTCA.
- CAE defined as a diameter enlargement ≥1.5 times adjacent normal segments.
- Comparison of CTCA measurements with CCA and thrombolysis in myocardial infarction (TIMI) frame count for flow velocity.
Main Results:
- CTCA identified CAE in 3% of patients.
- CTCA diameter measurements showed significant correlation with CCA (r=0.92, p<0.001).
- Lower contrast attenuation in ectatic segments correlated with CAE ratio and TIMI frame count, indicating flow alterations.
Conclusions:
- CTCA is a reliable method for assessing CAE prevalence and morphology.
- Contrast attenuation on CTCA reflects altered coronary blood flow in ectatic segments.
- CTCA offers valuable insights into CAE characteristics comparable to conventional methods.
Abstract:
To assess the prevalence and morphological characteristics of coronary artery ectasia (CAE) with CT coronary angiography (CTCA) in comparison to conventional catheterangiography (CCA). Dual-source CTCA examinations from 677 consecutive patients (223 women; median age 57 years) were retrospectively evaluated by two blinded observers for the presence of CAE defined as a diameter enlargement > or = 1.5 times the diameter of adjacent normal coronary segments. Vessel diameters and contrast attenuation within and proximal to ectatic segments were measured. CCA was used to compare measurements obtained from CTCA with the coronary flow velocity by using the thrombolysis in myocardial infarction (TIMI) frame count. CTCA identified CAE in 20 of 677 (3%) patients. CCA was performed in ten of these patients. CAE diameter measurements with CTCA (10.0 +/- 5.4 mm) correlated significantly (r = 0.92, p < 0.001) with the CCA measurements (8.8 +/- 4.9 mm), but had higher diameters (levels of agreement: -1.0 to 3.4 mm). Contrast attenuation was significantly lower in the ectatic (343 +/- 63 HU) than in the proximal (394 +/- 60 HU) segments (p < 0.01). The attenuation difference significantly correlated with the CAE ratio (r = 0.67, p < 0.01) and the TIMI frame count (r = 0.58, p < 0.05). The prevalence of CAE in a population examined by CTCA is around 3%. Contrast attenuation measurements with CTCA correlate well with the flow alterations assessed with CCA.
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