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Efficiency of a transtympanic approach to the round window membrane using a microendoscope
Harukazu Hiraumi1, Takayuki Nakagawa, Juichi Ito
1Department of Otolaryngology, Graduate School of Medicine, Kyoto University, Shogoin, Kyoto, Japan. hhiraumi@ent.kuhp.kyoto-u.ac.jp
Summary
A microendoscope effectively visualizes the round window membrane (RWM) via a transtympanic approach, improving cochlear drug delivery. This method overcomes anatomical barriers for targeted RWM drug placement.
Area of Science:
- Otolaryngology
- Neurosurgery
- Drug Delivery Systems
Background:
- Cochlear drug delivery via the round window membrane (RWM) is gaining interest.
- Anatomical challenges hinder direct RWM drug application.
Purpose of the Study:
- To evaluate the efficacy of a microendoscope for transtympanic RWM visualization.
- To compare microendoscopic and microscopic approaches for RWM access.
Main Methods:
- Ten human temporal bones were used.
- Four approaches were tested: transtympanic microendoscopic, transtympanic microscopic, transmastoid microendoscopic, and transmastoid microscopic.
- Transtympanic approaches involved tympanic membrane fenestration; transmastoid approaches used posterior hypotympanotomy.
Main Results:
- The transtympanic microendoscopic approach visualized the RWM in all specimens.
- The transtympanic microscopic approach visualized the RWM in only three specimens.
- The transmastoid approach allowed RWM visualization with both microendoscope and microscope in all specimens.
Conclusions:
- The transtympanic microendoscopic approach offers superior RWM visualization.
- This technique is a viable option for cochlear drug delivery through the RWM.
