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Related Experiment Video

Updated: Jul 3, 2026

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

The relationship between gender and age with monocyte tissue factor expression.

P Scully¹, P Tighe, G A Gilmore

¹Northern Ireland Centre for Diet and Health (NICHE), University of Ulster, Northern Ireland, UK. p.scully@ucc.ie

Journal of Thrombosis and Thrombolysis

|July 22, 2008

Summary

This study found no significant link between tissue factor (TF) expression and age or gender in participants. Therefore, increased cardiovascular disease (CVD) risk in older males may not stem from TF levels.

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Last Updated: Jul 3, 2026

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

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Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets

Published on: November 22, 2024

Area of Science:

Cardiovascular Science
Immunology
Hematology

Background:

Tissue factor (TF) expression on monocytes is typically low in healthy individuals.
Elevated TF levels are observed in patients with cardiovascular disease (CVD).
CVD risk increases with age and is higher in males, suggesting a potential link with TF.

Purpose of the Study:

To investigate the influence of age and gender on TF expression.
To explore the relationship between TF expression, BMI, and total fat intake.

Main Methods:

Evaluated TF expression in female (n=44) and male (n=27) subjects.
Assessed the impact of age, gender, BMI, and total fat intake on TF levels.

Main Results:

No significant differences in TF expression were found between male and female subgroups.
No correlation was observed between TF expression and age, BMI, or total fat intake in either gender.

Conclusions:

Age and gender do not appear to significantly influence TF expression in the study population.
Increased CVD risk in older males may not be attributable to elevated TF expression related to age or gender.