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Smoking, the oral contraceptive pill, and Crohn's disease
A J Wakefield1, A M Sawyerr, M Hudson
1Department of Medicine, Royal Free Hospital School of Medicine, London, England.
Digestive Diseases and Sciences
|August 1, 1991
Abstract:
Both cigarette smoking and the oral contraceptive pill have been implicated as aggravating factors in Crohn's disease. Based upon the recent demonstration of multifocal gastrointestinal infarction in Crohn's disease, a possible pathogenic mechanism for this condition, we propose how smoking and the oral contraceptive pill may potentiate a tendency for focal thrombosis and hence exacerbate the activity of Crohn's disease.