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Updated: Jul 3, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
Highly iodinated intravenous contrast material for PET/CT - a feasibility study
T A Heusner1, H Kuehl, P Veit-Haibach
1Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany.
Highly concentrated contrast media (HCCM) is feasible for PET/CT imaging, showing no significant impact on tracer uptake or artifacts. HCCM enhances CT attenuation, aiding PET attenuation correction in nuclear medicine.
Area of Science:
- Nuclear Medicine
- Radiology
- Medical Imaging
Background:
- Intravenous contrast materials (CM) improve PET/CT imaging but can affect tracer quantification and introduce artifacts.
- CT-based attenuation correction in PET/CT is crucial for accurate quantitative analysis.
Purpose of the Study:
- To evaluate the feasibility of using highly concentrated contrast media (HCCM, 400 mg iodine/ml) in PET/CT.
- To compare HCCM with lower concentrated contrast media (LCCM, 300 mg iodine/ml) regarding tracer quantification and image artifacts.
Main Methods:
- 60 whole-body FDG PET/CT scans were analyzed (30 with HCCM, 30 with LCCM).
- Tracer uptake (SUVmax) and CT attenuation (Hounsfield Units) were quantified at 16 anatomical positions.
- The incidence of potential PET artifacts was documented and statistically analyzed using the Mann-Whitney-Wilcoxon Test.
Main Results:
- HCCM did not significantly increase SUVmax (p > 0.05) or the number of PET artifacts (p = 0.69) compared to LCCM.
- HCCM significantly increased CT attenuation (p = 0.002) in 11 out of 16 positions.
Conclusions:
- The use of HCCM in PET/CT appears feasible and safe.
- HCCM warrants consideration for future PET/CT imaging protocols due to its potential benefits in attenuation correction.
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