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Effects of cefonicid on platelet aggregation.
M Cazzola1, G Santangelo, G Paizis
136th Division of Pneumology and Respiratory Allergy, A. Cardarelli Hospital, Naples, Italy.
Drugs Under Experimental and Clinical Research
|January 1, 1991
Summary
Beta-lactam antibiotics can impact platelet aggregation. This study found that therapeutic doses of cefonicid, a cephalosporin antibiotic, do not affect platelet aggregation in vitro.
Area of Science:
- Pharmacology
- Hematology
- Microbiology
Background:
- Beta-lactam antibiotics are known to potentially interfere with platelet aggregation.
- This interference may occur by inhibiting the binding of platelet aggregation agonists like ADP and collagen to their receptors.
Purpose of the Study:
- To investigate the in vitro effects of cefonicid, a semi-synthetic cephalosporin, on platelet aggregation.
- To determine if cefonicid impacts spontaneous and agonist-induced platelet aggregation.
Main Methods:
- Platelet aggregation was assessed in vitro using platelets from healthy subjects.
- Platelets were incubated with varying concentrations of cefonicid (0.1 mg/ml, 1 mg/ml, and 10 mg/ml).
- Aggregation was measured in response to spontaneous, ADP-induced, and collagen-induced stimulation.
Main Results:
- Cefonicid at a therapeutic concentration of 0.1 mg/ml showed no effect on platelet aggregation.
- At 1 mg/ml, cefonicid inhibited ADP-induced platelet aggregation.
- At 10 mg/ml, cefonicid inhibited both ADP- and collagen-induced platelet aggregation.
Conclusions:
- Therapeutic doses of cefonicid (0.1 mg/ml) do not appear to significantly affect platelet aggregation.
- Higher concentrations of cefonicid demonstrate inhibitory effects on platelet aggregation, particularly with collagen stimulation.