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Updated: Jul 3, 2026
Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
Published on: May 17, 2018
Development of a fatigue and functional impact scale in anemic cancer patients receiving chemotherapy
David Cella1, Hema N Viswanathan, Ron D Hays
1Center on Outcomes Research and Education, Evanston Northwestern Healthcare and Northwestern University, Evanston, Illinois 60201, USA. d-cella@northwestern.edu
Background:
This study was conducted to develop a brief measure of fatigue and functional impact in cancer patients with anemia.
Methods:
Data were obtained from a multisite, phase 2 study of darbepoetin-alpha (n = 1,558). Eligible patients were >or=18 years with nonmyeloid malignancies and anemia (hemoglobin
Results:
Data from 401 patients with complete data were used to identify 8 items for the Fatigue and Functional Impact Scale (FFIS), which was then evaluated using 1,355 of the 1,558 patients. The FFIS had an estimated internal consistency reliability of 0.90. The FFIS had significant correlations with the FACT-F (r = 0.94), FSI (r = 0.80), and BFI (r = 0.86), from which it was derived. The FFIS also correlated substantially with single-item measures of energy (r = 0.75) and productivity (r = 0.72).
Conclusions:
The FFIS is a reliable, brief, and practical tool that is potentially suitable for identifying fatigue and functional impact in cancer patients.
