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Updated: Jul 3, 2026

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
[Correlation between FoxP3(+) regulatory T cells and chronic obstructive pulmonary disease]
Xian-Zhi Xiong1, Yang Jin, Qiong Zhou
1Department of Respiratory Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. xxz0508@yahoo.com.cn
Regulatory T cells (Treg) are present in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). These CD4(+)Treg and CD8(+)Treg cells are linked to immune suppression and can serve as novel biomarkers for COPD patients.
Area of Science:
- Immunology
- Respiratory Medicine
Context:
- Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung disease.
- Acute exacerbations of COPD (AECOPD) involve significant inflammatory responses.
- Regulatory T cells (Treg) play a crucial role in immune system regulation.
Purpose:
- To determine the presence and quantify CD4(+) and CD8(+) FoxP3(+) regulatory T cells (Treg) in patients experiencing AECOPD.
- To investigate the correlation between Treg cell populations and clinical parameters in AECOPD.
Summary:
- Flow cytometry analysis revealed the presence of both CD4(+)Treg and CD8(+)Treg cells in the peripheral blood of AECOPD patients.
- Treg cell quantities and percentages showed significant correlations with age, disease duration, smoking index, white blood cell count, and blood pH.
- No significant correlation was found between Treg cells and TGF-beta1 or IL-10 levels.
Impact:
- The findings indicate that CD4(+)Treg and CD8(+)Treg cells are involved in the immune suppression observed in AECOPD.
- These Treg cell populations represent potential novel immunological markers for assessing disease status in AECOPD patients.
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