Isostructural self-assembly of 2'-deoxyguanosine derivatives in aqueous and organic media
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Updated: Jul 3, 2026

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
Marilyn García-Arriaga1, Gerard Hobley, José M Rivera
1Department of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, Puerto Rico.
Abstract:
We report the self-assembly of a hydrophilic 8-(m-acetylphenyl)-2'-deoxyguanosine (mAG) derivative into a discrete and thermally stable hexadecameric supramolecule in aqueous media. We demonstrate that this hexadecamer is isostructural to the one formed by a related lipophilic derivative in organic media. This mAG moiety represents a rare example of a small-molecule recognition motif that is capable of assembling isostructurally and with high fidelity in both organic and aqueous media.
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