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A Novel Ex Ovo Banding Technique to Alter Intracardiac Hemodynamics in an Embryonic Chicken System
Published on: May 13, 2016
During vertebrate development, arteries exert a morphological control over the venous pattern through physical
Alia Al-Kilani1, Sylvie Lorthois, Thi-Hanh Nguyen
1Groupe Matière Condensée et Matériaux, Université de Rennes 1, Campus de Beaulieu, Bâtiment 13A, 35 042 Rennes, France.
Summary
Arteries guide venous pattern development by remodeling capillaries, creating parallel pathways as organisms grow. This shift from sequential to parallel vessel arrangement is a general principle in vascular morphogenesis.
Area of Science:
- Developmental Biology
- Vascular Biology
- Biophysics
Background:
- The adult vasculature comprises arteries, capillaries, and veins, organized in series for blood flow.
- The spatial organization of vascular networks, particularly the relationship between arteries and veins, is complex and not fully understood.
- During vertebrate development, a transition occurs from a sequential (cis-cis) to a parallel (cis-trans) arterial-venous configuration.
Purpose of the Study:
- To elucidate the mechanisms by which arteries control venous pattern formation.
- To explain the transition from cis-cis to cis-trans configurations in developing vasculature.
- To understand the role of tissue growth and capillary remodeling in vascular morphogenesis.
Main Methods:
- Utilized physical arguments and theoretical modeling.
- Incorporated experimental evidence from literature.
- Analyzed in situ optical and mechanical measurements of chick embryo vasculature.
Main Results:
- Arteries induce venous pattern formation through capillary tissue remodeling.
- This remodeling creates a prepattern for parallel venous growth.
- Tissue growth favors this prepatterned path, leading to the emergence of the cis-trans configuration.
- Self-organization principles contribute to the final vascular pattern.
Conclusions:
- Arterial influence on capillary remodeling is a key driver of venous pattern development.
- The transition to parallel arterial-venous arrangements is a predictable outcome of organismal growth.
- Vascular morphogenesis is a self-organizing process influenced by physical constraints and growth dynamics.
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