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Related Experiment Videos

Shuffled domains in extracellular proteins.

P Bork1

  • 1Central Institute of Molecular Biology, Berlin, Germany.

FEBS Letters
|July 29, 1991
PubMed
Summary

Researchers identified approximately 40 distinct domains within extracellular mosaic proteins. These domains form a structural network, suggesting a basis for coordinating diverse protein functions in extracellular environments.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Background:

  • Extracellular mosaic proteins play crucial roles in cellular processes.
  • Understanding the domain organization of these proteins is essential for elucidating their functions.

Purpose of the Study:

  • To comprehensively identify and catalog domains within extracellular mosaic proteins.
  • To investigate the potential structural and functional implications of these domains.

Main Methods:

  • Analysis of protein sequences to identify conserved consensus patterns.
  • Database searches to recognize identified domains in a broader set of extracellular proteins.

Main Results:

  • Approximately 40 distinct domains were identified in extracellular mosaic proteins.
  • These domains were found in over 200 extracellular proteins, indicating widespread occurrence.
  • Evidence suggests these domains form a structural network.

Conclusions:

  • The identified domains represent fundamental building blocks of extracellular mosaic proteins.
  • The proposed structural network provides a molecular basis for coordinating diverse extracellular functions.

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