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Updated: Jul 3, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Structural proteomics of dengue virus.

Rushika Perera¹, Richard J Kuhn

¹Markey Center for Structural Biology & Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, United States.

Current Opinion in Microbiology

|July 23, 2008

Summary

New structural data reveals key insights into the dengue virus life cycle. Understanding the dengue virus proteins, like NS3 and NS5, aids in predicting host interactions and developing antiviral strategies.

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Area of Science:

Virology
Structural Biology
Molecular Biology

Background:

The dengue virus life cycle is complex and not fully understood.
Structural information of viral proteins is crucial for deciphering viral mechanisms.
Previous knowledge gaps existed regarding key dengue virus proteins.

Purpose of the Study:

To present recent advances in understanding the dengue virus life cycle.
To highlight the significance of new structural data for viral proteins.
To provide a structural basis for understanding viral function and host interactions.

Main Methods:

Analysis of newly solved structures of dengue virus proteins.
Focus on pre-membrane protein (prM), NS3, and NS5 domains.
Integration of structural data with functional and interactional predictions.

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Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen

Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen

Published on: January 26, 2024

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Last Updated: Jul 3, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen

Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen

Published on: January 26, 2024

Main Results:

Detailed structural insights into the pre-membrane protein (prM) and its role in virus assembly.
The first full-length structure of the multi-domain dengue virus replication protein NS3.
Solved structures of the NS5 methyltransferase and polymerase domains.

Conclusions:

New structural data significantly advances the understanding of the dengue virus life cycle.
The elucidated structures provide a foundation for functional analysis of viral proteins.
These findings facilitate the prediction of potential host-virus interactions, aiding therapeutic development.