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Updated: Jul 3, 2026
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High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem
Published on: December 30, 2015
Method for cotemporal and coplanar comparison of magnetic resonance imaging and neuropathology of formalin-fixed
Abstract:
We describe the design and production of a mitre box that allows magnetic resonance imaging and pathological sectioning of a formalin-fixed brain so that the pathological and radiological slices are coplanar and therefore readily comparable.
Insights
A novel mitre box enables simultaneous magnetic resonance imaging and pathological sectioning of formalin-fixed brains. This ensures radiological and pathological slices are aligned for direct comparison.
Area of Science:
- Neuroscience
- Medical Imaging
- Pathology
Background:
- Accurate comparison of radiological and pathological brain slices is crucial for diagnosis.
- Current methods may lead to misalignment between imaging and sectioning planes.
Purpose of the Study:
- To design and produce a specialized mitre box for brain specimen preparation.
- To achieve coplanar magnetic resonance imaging and pathological sectioning of formalin-fixed brains.
Main Methods:
- Development of a custom-designed mitre box apparatus.
- Integration of magnetic resonance imaging (MRI) compatibility with precise pathological sectioning.
- Utilizing formalin-fixed brain specimens.
Main Results:
- The mitre box facilitates the production of aligned radiological and pathological brain slices.
- Ensures that imaging slices and physical sections are in the same plane.
- Enables direct, accurate comparison between MRI and histopathological findings.
Conclusions:
- The developed mitre box is an effective tool for comparative neuropathological analysis.
- It improves the correlation between in-vivo imaging and ex-vivo pathological examination.
- This technique enhances diagnostic accuracy in brain pathology research.
