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Updated: Jul 3, 2026
05:22
Rapid Collection of Floral Fragrance Volatiles using a Headspace Volatile Collection Technique for GC-MS Thermal Desorption Sampling
Published on: December 10, 2019
Fragrance material review on (-)-alpha-terpineol.
S P Bhatia1, C S Letizia, A M Api
1Research Institute for Fragrance Materials Inc., Woodcliff Lake, NJ 07677, USA. sbhatia@rifm.org
Summary
This review examines the toxicologic and dermatologic safety of p-menth-1-en-8-ol (S), a common fragrance ingredient. It provides a comprehensive safety assessment for this widely used chemical compound.
Area of Science:
- Toxicology
- Dermatology
- Fragrance Chemistry
Background:
- p-menth-1-en-8-ol (S) is a naturally occurring monoterpene alcohol found in essential oils.
- It is frequently utilized as a fragrance ingredient in various consumer products.
- Understanding its toxicologic and dermatologic profile is crucial for consumer safety.
Purpose of the Study:
- To conduct a comprehensive toxicologic and dermatologic review of p-menth-1-en-8-ol (S).
- To evaluate the safety of p-menth-1-en-8-ol (S) as a fragrance ingredient.
- To consolidate existing data on the safety of this compound.
Main Methods:
- Literature review of existing toxicologic and dermatologic studies.
- Analysis of data from regulatory assessments and scientific publications.
- Evaluation of potential adverse effects associated with topical exposure.
Main Results:
- The review synthesizes available data on the safety of p-menth-1-en-8-ol (S).
- Identifies potential dermatologic effects and toxicologic endpoints.
- Highlights areas where further research may be warranted.
Conclusions:
- p-menth-1-en-8-ol (S) is generally considered safe for use as a fragrance ingredient at typical concentrations.
- Potential for skin sensitization exists, necessitating careful formulation.
- Further investigation into specific exposure scenarios may enhance risk assessment.
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