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Oxidative imbalance in adult attention deficit/hyperactivity disorder
Salih Selek1, Haluk A Savas, H Serdar Gergerlioglu
1Psychiatry Department, Kahramanmaras State Hospital, K Maras, Turkey.
Objective:
There are few studies evaluating the biochemical basis of adult attention deficit/hyperactivity disorder (A-ADHD). In the present study, we evaluated whether nitric oxide (NO), an oxidant, level and superoxide dismutase (SOD), an antioxidant, activity are associated with A-ADHD or not.
Methods:
Twenty A-ADHD patients from Gaziantep University Sahinbey Research Hospital, Psychiatry Clinic, diagnosed according to The Turkish version of Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale by two psychiatrists (H.A.S. and S.S.), and twenty-one healthy volunteer controls were included. Blood samples were collected; NO levels and SOD activities were measured.
Results:
The mean NO levels in patients were significantly higher than those of controls and SOD activity of patients was significantly lower than controls.
Conclusions:
Remarkable high levels of oxidant NO, and low SOD activities suggest an oxidative imbalance in A-ADHD. This is the first study evaluating the oxidative metabolism in A-ADHD.
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