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Related Experiment Video

Updated: Jul 3, 2026

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors

Published on: September 18, 2013

CXCL12/CXCR4 signalling in neuronal cell migration.

Marie-Catherine Tiveron¹, Harold Cremer

¹Developmental Biology Institute of Marseille-Luminy, CNRS/University Méditerranée, Campus de Luminy, Case 907, 13288 Marseille cedex 9, France.

Current Opinion in Neurobiology

|July 23, 2008

Summary

The CXCL12/CXCR4 system regulates cell migration in the developing nervous system, particularly in the cerebellum and cortex. Its functions are further understood with the discovery of CXCR7, a second receptor for CXCL12.

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Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

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Area of Science:

Neuroscience
Molecular Biology
Developmental Biology

Background:

The chemokine CXCL12 (SDF-1) and its receptor CXCR4 are known immune system regulators.
Recent findings highlight their crucial role in neural cell migration during nervous system development.

Purpose of the Study:

To review the functions of the CXCL12/CXCR4 system in neural development.
To focus on cell migration in the cerebellum and cortex.
To discuss these roles alongside the newly identified CXCL12 receptor, CXCR7.

Main Methods:

Literature review of studies on CXCL12/CXCR4 signaling in neural development.
Analysis of cell migration patterns in the developing cerebellum and cortex.
Integration of findings on CXCR7 function, including studies in zebrafish.

Main Results:

The CXCL12/CXCR4 system is a key regulator of neuronal migration in the developing brain.
Specific roles in cerebellar and cortical development have been elucidated.
The second receptor, CXCR7, adds complexity to CXCL12 signaling pathways.

Conclusions:

The CXCL12/CXCR4/CXCR7 axis plays a significant role in orchestrating cell migration essential for proper nervous system formation.
Understanding this system provides insights into developmental processes and potential therapeutic targets.