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Effect of IgG immunoadsorption on serum cytokines in MG and LEMS patients

Fulvio Baggi1, Federica Ubiali, Sara Nava

  • 1Neurology IV, Neurological Institute Foundation "Carlo Besta", Via Celoria 11, 20133 Milan, Italy. baggi@istituto-besta.it

Journal of Neuroimmunology
|July 23, 2008
PubMed

We investigated the effect of IgG immunoadsorption (IA) on cytokine network in patients with treatment-resistant Myasthenia Gravis (MG) and Lambert-Eaton Syndrome (LEMS). We observed upregulation of interleukin (IL)-10, an anti-inflammatory and B cells growth factor, and reduction of pro-inflammatory factors such as IL-18 and IL-17, in both MG and LEMS after IA. Our observation suggests that the massive removal of antibodies might induce modifications of the cytokine balance linked to T and B cells mediated autoimmunity.

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