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Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability

Sigrid A Rajasekaran1, Jason J Christiansen, Ingrid Schmid

  • 1Nemours Center for Childhood Cancer Research, Alfred I. DuPont Hospital for Children, Rockland Center I, 1701 Rockland Road, Wilmington, DE 19803, USA.

Molecular Cancer Therapeutics
|July 23, 2008
PubMed

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
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