Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 3, 2026

Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery
11:49

Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery

Published on: April 3, 2026

Breast sentinel lymph node dissection before preoperative chemotherapy.

Baiba J Grube1, Carla J Christy, Dalliah Black

  • 1Departmentof Surgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

Archives of Surgery (Chicago, Ill. : 1960)
|July 23, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

User-Friendly Summary of BI-RADS v2025: What Practicing Radiologists Want to Know.

AJR. American journal of roentgenology·2026
Same author

Peri-lymphatic cytokines (IRX-2) as immunologic induction preceding neoadjuvant chemo-immunotherapy in triple-negative breast cancer.

NPJ breast cancer·2026
Same author

Assessing healthcare access among residents in rural Eastern San Diego county: a qualitative study.

BMC primary care·2026
Same author

Characteristics and dynamical signatures of recurrent cortical circuits during context-dependent processing.

bioRxiv : the preprint server for biology·2026
Same author

Crizotinib in Patients with Tumors with MET Amplification or Exon 14 Deletion: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocols C1 and C2.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Inpainting the Neural Picture: Inferring Unrecorded Brain Area Dynamics from Multi-Animal Datasets.

ArXiv·2025
Same journal

The White Test: A New Dye Test for Intraoperative Detection of Bile Leakage During Major Liver Resection-Invited Critique.

Archives of surgery (Chicago, Ill. : 1960)·2017
Same journal

Use of Vascular Clamping in Hepatic Surgery: Lessons Learned From 1260 Liver Resections-Invited Critique.

Archives of surgery (Chicago, Ill. : 1960)·2017
Same journal

Randomized Clinical Trial of Small-Incision and Laparoscopic Cholecystectomy in Patients With Symptomatic Cholecystolithiasis: Primary and Clinical Outcomes-Invited Critique.

Archives of surgery (Chicago, Ill. : 1960)·2017
Same journal

Liver Resection With a New Multiprobe Bipolar Radiofrequency Device-Invited Critique.

Archives of surgery (Chicago, Ill. : 1960)·2017
Same journal

Porcine and Bovine Surgical Products: Jewish, Muslim, and Hindu Perspectives-Invited Critique.

Archives of surgery (Chicago, Ill. : 1960)·2017
Same journal

Neuroendocrine Liver Metastasis: Transplant as Part of Multimodality Liver-Directed Therapy-Reply.

Archives of surgery (Chicago, Ill. : 1960)·2016
See all related articles

Performing sentinel lymph node dissection before chemotherapy accurately stages the breast cancer axilla. Even after chemotherapy, many patients still have residual lymph node disease, impacting treatment decisions.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Breast Cancer Research

Background:

  • The optimal timing for sentinel lymph node dissection (SLND) in breast cancer patients receiving preoperative chemotherapy (PC) remains a subject of debate.
  • Accurate staging of axillary lymph nodes is crucial for determining prognosis and guiding treatment strategies.

Purpose of the Study:

  • To evaluate the feasibility and accuracy of performing SLND before PC in patients with invasive breast cancer.
  • To compare the rates of residual nodal disease after PC in patients who underwent SLND before or after neoadjuvant therapy.

Main Methods:

  • A single-institution retrospective analysis of prospectively collected data from the Yale-New Haven Breast Center Database.
  • Fifty-five patients with clinically node-negative invasive breast cancer underwent SLND before PC.

More Related Videos

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

Related Experiment Videos

Last Updated: Jul 3, 2026

Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery
11:49

Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery

Published on: April 3, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

  • Results were compared to a control group (n=463) who had SLND and definitive surgery before chemotherapy.

    • Main Results:

    • Sentinel node identification rate was 100% with a 0% clinical false-negative rate when SLND was performed before PC.
    • Of patients with positive sentinel nodes before PC, 55% had no additional positive nodes after PC, indicating downstaging.
    • However, a significant percentage (45%) still had residual nodal disease requiring axillary lymph node dissection.

    Conclusions:

    • Sentinel lymph node dissection before preoperative chemotherapy provides accurate axillary staging for breast cancer patients.
    • Preoperative chemotherapy can downstage nodal disease, but a substantial proportion of patients retain residual axillary metastases, necessitating careful management.