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Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

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Related Experiment Video

Updated: Jul 3, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
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Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

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Body composition and pulmonary function in the elderly: a 7-year longitudinal study.

A Rossi1, F Fantin, V Di Francesco

  • 1Division of Geriatrics, University of Verona, Verona, Italy.

International Journal of Obesity (2005)
|July 23, 2008
PubMed
Summary
This summary is machine-generated.

In older adults, increased abdominal fat and loss of fat-free mass (FFM) significantly predict declines in pulmonary function. Elderly individuals experiencing both abdominal fat gain and FFM loss are most likely to see worsening lung function.

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Evaluating the Function of the Foot Core System in the Elderly
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Last Updated: Jul 3, 2026

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Area of Science:

  • Gerontology
  • Pulmonology
  • Body Composition Research

Background:

  • Aging is associated with changes in body composition and potential declines in pulmonary function.
  • Understanding the interplay between body composition, fat distribution, and lung function in the elderly is crucial for health management.

Purpose of the Study:

  • To investigate the 7-year longitudinal relationships between changes in body composition, abdominal fat distribution, and pulmonary function in elderly men and women.

Main Methods:

  • A longitudinal clinical study followed 77 elderly individuals (47 women, 30 men) for 7 years.
  • Measurements included body weight, waist circumference, sagittal abdominal diameter (SAD), fat-free mass (FFM) via DXA, and spirometry (FEV1, FVC).

Main Results:

  • Significant decreases in height and FFM were observed in both sexes over 7 years.
  • Height-adjusted FEV1 and FVC significantly declined in both men and women.
  • Increased SAD was a strong predictor of reduced FEV1 and FVC; a 1 cm SAD increase predicted a decrease of 31 ml in FEV1 and 46 ml in FVC.
  • A 1 kg FFM decrease predicted a 38 ml decrease in FVC.
  • Elderly individuals with decreased FFM and increased SAD showed the highest probability of lung function decline.

Conclusions:

  • Increases in abdominal fat and declines in FFM are significant predictors of pulmonary function decline in the elderly population.
  • Simultaneous abdominal fat gain and FFM loss in older adults are associated with the greatest risk of worsening lung function.