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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Western Blotting01:15

Western Blotting

Western blotting is an analytical technique for protein identification. It has various applications in immunology and medicine, including detecting diseases like bovine spongiform encephalopathy, mad cow disease, and human and feline immunodeficiency virus from biological samples.
The technique begins with separating proteins from the sample using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), followed by protein transfer, immunoblotting, and finally, protein detection.

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Related Experiment Video

Updated: Jul 3, 2026

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples
13:21

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples

Published on: May 4, 2012

Microarray methods for protein biomarker detection.

Hye Jin Lee1, Alastair W Wark, Robert M Corn

  • 1Department of Chemistry, Kyungpook National University, Daegu 702-701, South Korea. hyejinlee@knu.ac.kr

The Analyst
|July 23, 2008
PubMed
Summary
This summary is machine-generated.

Protein biomarker research is advancing disease detection and treatment. Microarray technology enables high-throughput profiling for earlier, more accurate diagnoses and personalized medicine.

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Related Experiment Videos

Last Updated: Jul 3, 2026

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples
13:21

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples

Published on: May 4, 2012

Extracellular Protein Microarray Technology for High Throughput Detection of Low Affinity Receptor-Ligand Interactions
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Extracellular Protein Microarray Technology for High Throughput Detection of Low Affinity Receptor-Ligand Interactions

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Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions
08:07

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

Published on: August 2, 2015

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Medical Diagnostics

Background:

  • Protein biomarkers are crucial for disease detection and treatment.
  • Assaying biomarkers in biological fluids (serum, urine) aids non-invasive diagnosis and targeted therapy.
  • High-throughput screening of numerous proteins is vital for biomarker discovery.

Purpose of the Study:

  • To review recent advancements in microarray technology for biomarker profiling.
  • To discuss the challenges in developing and implementing high-throughput biomarker assays.

Main Methods:

  • Utilizing microarrays for simultaneous screening of large protein numbers.
  • Focusing on high sensitivity and selectivity in protein detection.

Main Results:

  • Microarrays facilitate high-throughput biomarker profiling.
  • Progress has been made in sensitive and selective protein detection.

Conclusions:

  • Microarray technology shows significant promise for advancing biomarker discovery.
  • Overcoming current challenges is key to realizing the full potential of biomarker profiling for improved patient care.