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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Calcium supplementation and vascular disease.

I R Reid¹, M J Bolland

¹Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Climacteric : the Journal of the International Menopause Society

|July 23, 2008

Summary

Calcium supplements may increase vascular event risks, including heart attacks, especially in postmenopausal women. This finding warrants careful consideration when advising on calcium intake.

Area of Science:

Cardiovascular Health
Bone Metabolism
Nutritional Science

Background:

Calcium supplementation is widely used for preventing postmenopausal bone loss.
Potential benefits for blood pressure and cholesterol have been proposed.
The impact of calcium on vascular disease remains an area of investigation.

Purpose of the Study:

To investigate the effects of calcium supplementation on vascular disease in healthy postmenopausal women.
To assess the relationship between calcium intake and cardiovascular events.

Main Methods:

A large, randomized, controlled trial was conducted over 5 years.
The study included healthy postmenopausal women.
Compliance with calcium supplements was monitored.

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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Main Results:

A significant increase in vascular event rates, particularly myocardial infarction, was observed in the calcium group.
Higher compliance with calcium supplements correlated with more pronounced adverse effects.
Similar adverse trends were noted in other recent studies, though not always statistically significant.

Conclusions:

Calcium supplementation may be associated with increased vascular event rates in postmenopausal women.
The findings suggest a potential acceleration of vascular disease in patients with renal impairment.
Further research is crucial to understand the risks and benefits of calcium supplementation for vascular health.