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Plasma advanced glycation end products are decreased in obese children compared with lean controls

Katarĺna Sebeková1, Veronika Somoza, Monika Jarcusková

  • 1Department of Clinical and Experimental Pharmacotherapy, Slovak Medical University, Limbová 14, Bratislava 833 03, Slovakia. katarina.sebekova@szu.sk

International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity
|July 23, 2008
PubMed

Insights

Childhood obesity shows lower plasma advanced glycation end products (AGEs) despite increased oxidative stress and inflammation. Enhanced kidney filtration may explain reduced AGEs in obese youth.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Nephrology

Background:

  • Obesity in children and adolescents is linked to increased oxidative stress, microinflammation, and potentially advanced glycation end products (AGEs).
  • The role of AGEs and their receptor (sRAGE) in pediatric obesity, considering metabolic and renal factors, requires further investigation.

Purpose of the Study:

  • To compare plasma AGEs, sRAGE, oxidative stress markers, microinflammation, and renal function in obese versus lean children and adolescents.
  • To investigate the relationship between these parameters and insulin resistance in pediatric obesity.

Main Methods:

  • Cross-sectional study comparing 18 obese and 18 lean children/adolescents.
  • Assessed plasma N(epsilon)-carboxymethyllysine (CML), fructoselysine (FL), AGE-associated fluorescence, sRAGE, high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), urinary 8-hydroxy-2-deoxyguanosine (U-8-OHdG), plasma advanced oxidation protein products (AOPPs), and HOMA index.
  • Evaluated renal function including creatinine clearance and proteinuria.

Main Results:

  • Obese youth had significantly lower plasma FL, CML, and fluorescent AGEs compared to lean controls.
  • Despite lower AGEs, obese children exhibited increased insulin resistance, inflammation (hs-CRP, IL-6), oxidative stress (AOPPs, U-8-OHdG), and higher creatinine clearance and proteinuria.
  • Plasma sRAGE concentrations did not differ between groups.

Conclusions:

  • Childhood/adolescent obesity is paradoxically associated with lower plasma AGE levels, contrary to expectations based on metabolic and inflammatory profiles.
  • Enhanced renal hyperfiltration in obese youth may contribute to increased clearance of AGE peptides, thus lowering plasma concentrations.
Abstract

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