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Morphometric and histologic changes in the pulmonary system of broilers raised at simulated high altitude
R L Owen1, R F Wideman, G F Barbato
1Department of Veterinary Science, Pennsylvania State University, University Park, USA.
Avian Pathology : Journal of the W.V.P.A
|June 1, 1995
Summary
Hypobaric hypoxia, simulating high altitude, did not significantly increase pulmonary nodules in broilers. However, it did increase packed cell volume and electrocardiogram QRS amplitude, indicating physiological stress.
Area of Science:
- Veterinary Pathology
- Avian Physiology
- High-Altitude Research
Background:
- Broiler pulmonary hypertension syndrome (BPHS) is a significant concern in poultry production.
- Understanding the impact of environmental stressors like hypobaric hypoxia is crucial for broiler health.
Purpose of the Study:
- To investigate the development of pulmonary nodules in broilers under hypobaric hypoxia.
- To compare pulmonary morphometrics, packed cell volume, and electrocardiogram QRS amplitude in birds with and without BPHS at high altitude versus ambient pressure.
Main Methods:
- Broilers were reared in hypobaric hypoxia (3500 m) and at ambient pressure.
- Groups included birds developing BPHS, unaffected hypoxic birds, and control birds.
- Measurements included gross pulmonary morphometrics, packed cell volume, and electrocardiogram QRS amplitude.
Main Results:
- Hypobaric hypoxia alone had minimal effect on pulmonary nodule development.
- Nodule counts and areas were numerically higher in hypoxic birds but not significantly different in BPHS cases.
- Packed cell volume and electrocardiogram QRS amplitude were significantly elevated in birds exposed to hypobaric hypoxia.
Conclusions:
- High altitude conditions alone do not appear to be a primary driver for pulmonary nodule formation in broilers.
- Physiological markers of stress (packed cell volume, QRS amplitude) are elevated in broilers exposed to hypobaric hypoxia, irrespective of BPHS development.
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