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Relationship between serum adiponectin and prostate cancer grade
David J Sher1, William K Oh, Susanna Jacobus
1Harvard Radiation Oncology Program, Boston, Massachusetts 02115, USA.
The Prostate
|July 23, 2008
Summary
Lower serum adiponectin levels were linked to higher-grade prostate cancer (PCA) in men who underwent radical prostatectomy (RP). This finding suggests adiponectin may play a role in PCA progression, despite no association with biopsy-grade disease.
Area of Science:
- Oncology
- Endocrinology
- Urology
Background:
- Obesity is linked to prostate cancer (PCA) grade, but mechanisms are unclear.
- Adiponectin, an adipokine, is implicated in hormonally sensitive carcinomas.
- This study investigates serum adiponectin and Gleason score (GS) in PCA patients.
Purpose of the Study:
- To evaluate the relationship between serum adiponectin levels and Gleason score (GS) in prostate cancer patients.
- To determine if adiponectin is associated with high-grade prostate cancer (defined as GS ≥ 7).
Main Methods:
- Prospective study of localized PCA patients (2001-2005) with serum banking.
- Exclusion of patients with prior hormonal therapy or metastatic disease.
- Logistic regression used to assess association between high-grade disease and adiponectin, adjusting for prognostic variables.
Main Results:
- 539 patients included; 199 underwent radical prostatectomy (RP).
- No association found between biopsy GS and serum adiponectin.
- Lower adiponectin levels were significantly associated with higher pathological GS in men undergoing RP (P=0.014).
Conclusions:
- Serum adiponectin is not associated with biopsy-detected prostate cancer grade.
- Lower adiponectin levels are independently associated with high-grade prostate cancer in men after RP.
- Adiponectin may be a prognostic marker for prostate cancer progression.
