Related Experiment Video
Updated: Jul 3, 2026
A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
Interventions for preventing depression after stroke
Maree L Hackett1, Craig S Anderson, Allan House
1Department of Neurological and Mental Health, George Institute for International Health, PO Box M201, Missenden Road, Sydney, NSW, Australia, 2050. mhackett@thegeorgeinstitute.org
Insights
Psychological interventions show a small but significant effect in preventing depression and improving mood after stroke. Pharmaceutical treatments did not demonstrate clear benefits for stroke patients.
Area of Science:
- Neurology
- Psychiatry
- Clinical Trials
Background:
- Post-stroke depression significantly impacts patient recovery.
- Often, depression following stroke is undetected or inadequately treated.
Purpose of the Study:
- To evaluate the efficacy of pharmaceutical and psychological interventions in preventing depression post-stroke.
- To assess the impact of these interventions on physical and psychological outcomes.
Main Methods:
- Systematic review of randomized controlled trials comparing pharmaceutical agents versus placebo and psychotherapy versus standard care.
- Searched multiple databases including Cochrane, MEDLINE, EMBASE, PsycINFO, and others up to 2008.
- Two independent reviewers selected trials, extracted data, and assessed quality; primary outcome was depression diagnosis, secondary outcomes included mood scores and functional status.
Main Results:
- Fourteen trials with 1515 participants were analyzed.
- Pharmacological therapy showed no clear effect on preventing depression or improving other outcomes.
- Psychotherapy demonstrated a significant improvement in mood and depression prevention, although effect sizes were small.
Conclusions:
- Psychotherapy offers a small but statistically significant benefit for mood and depression prevention in stroke survivors.
- Further research is needed to establish recommendations for routine psychotherapy use after stroke.
Background:
Depression is an important consequence of stroke that impacts on recovery yet often is not detected or is inadequately treated.
Objectives:
To determine if pharmaceutical or psychological interventions can prevent depression and improve physical and psychological outcomes in patients with stroke.
Search Strategy:
We searched the Trials Registers of the Cochrane Stroke Group (October 2007) and the Cochrane Depression Anxiety and Neurosis Group (February 2008). In addition, we searched the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 1, 2008), MEDLINE (1966 to May 2006), EMBASE (1980 to May 2006), CINAHL (1982 to May 2006), PsycINFO (1967 to May 2006), Applied Science and Technology Plus (1986 to May 2006), Arts and Humanities Index (1991 to September 2002), Biological Abstracts (1969 to September 2002), BIOSIS Previews (2002 to May 2006), General Science Plus (1994 to September 2002), Science Citation Index (1992 to May 2006), Social Sciences Citation Index (1991 to May 2006), SocioFile (1974 to May 2006) ISI Web of Science (2002 to February 2008), reference lists, trial registers, conference proceedings and dissertation abstracts, and contacted authors, researchers and pharmaceutical companies.
Selection Criteria:
Randomised controlled trials comparing pharmaceutical agents with placebo, or psychotherapy against standard care (or attention control) to prevent depression in patients with stroke.
Data Collection And Analysis:
Two review authors independently selected trials, extracted data and assessed trial quality. Primary analyses were the proportion of patients who met the standard diagnostic criteria for depression applied in the trials at the end of follow up. Secondary outcomes included depression scores on standard scales, physical function, death, recurrent stroke and adverse effects.
Main Results:
Fourteen trials involving 1515 participants were included. Data were available for 10 pharmaceutical trials (12 comparisons) and four psychotherapy trials. The time from stroke to entry ranged from a few hours to seven months, but most patients were recruited within one month of acute stroke. The duration of treatment ranged from two weeks to one year. There was no clear effect of pharmacological therapy on the prevention of depression or other endpoints. A significant improvement in mood and the prevention of depression was evident for psychotherapy, but the treatment effects were small.
Authors' Conclusions:
A small but significant effect of psychotherapy on improving mood and preventing depression was identified. More evidence is required before recommendations can be made about the routine use of such treatments after stroke.
Related Concept Videos
01:28Acute Coronary Syndrome IV: Interprofessional Care
01:23Atherosclerosis IV: Nursing Management
01:18Depression: Overview
01:30Electroconvulsive Therapy
01:24Treatment Strategies for Psychological Disorders
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
01:15Ischemic Stroke l: Introduction