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Updated: Jul 3, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Interventions for preventing depression after stroke.

Maree L Hackett1, Craig S Anderson, Allan House

  • 1Department of Neurological and Mental Health, George Institute for International Health, PO Box M201, Missenden Road, Sydney, NSW, Australia, 2050. mhackett@thegeorgeinstitute.org

The Cochrane Database of Systematic Reviews
|July 23, 2008
PubMed
Summary
This summary is machine-generated.

Psychological interventions show a small but significant effect in preventing depression and improving mood after stroke. Pharmaceutical treatments did not demonstrate clear benefits for stroke patients.

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Published on: January 9, 2026

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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
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Published on: May 22, 2019

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint
06:45

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Published on: January 9, 2026

Area of Science:

  • Neurology
  • Psychiatry
  • Clinical Trials

Background:

  • Post-stroke depression significantly impacts patient recovery.
  • Often, depression following stroke is undetected or inadequately treated.

Purpose of the Study:

  • To evaluate the efficacy of pharmaceutical and psychological interventions in preventing depression post-stroke.
  • To assess the impact of these interventions on physical and psychological outcomes.

Main Methods:

  • Systematic review of randomized controlled trials comparing pharmaceutical agents versus placebo and psychotherapy versus standard care.
  • Searched multiple databases including Cochrane, MEDLINE, EMBASE, PsycINFO, and others up to 2008.
  • Two independent reviewers selected trials, extracted data, and assessed quality; primary outcome was depression diagnosis, secondary outcomes included mood scores and functional status.

Main Results:

  • Fourteen trials with 1515 participants were analyzed.
  • Pharmacological therapy showed no clear effect on preventing depression or improving other outcomes.
  • Psychotherapy demonstrated a significant improvement in mood and depression prevention, although effect sizes were small.

Conclusions:

  • Psychotherapy offers a small but statistically significant benefit for mood and depression prevention in stroke survivors.
  • Further research is needed to establish recommendations for routine psychotherapy use after stroke.