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Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
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Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
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Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...

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Updated: Jul 3, 2026

Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review
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Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review

Published on: November 8, 2024

Cauda equina syndrome: an anatomically driven review.

C Mauffrey1, K Randhawa, C Lewis

  • 1Solihull Hospital.

British Journal of Hospital Medicine (London, England : 2005)
|July 24, 2008
PubMed
Summary
This summary is machine-generated.

Cauda equina syndrome, a rare complication of lumbar disc surgery, affects nerve roots controlling bladder, bowel, and sexual function. This review details its anatomy, symptoms, and acute management strategies for affected patients.

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Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review
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Published on: November 8, 2024

Spinal Cord Lateral Hemisection and Asymmetric Behavioral Assessments in Adult Rats
08:46

Spinal Cord Lateral Hemisection and Asymmetric Behavioral Assessments in Adult Rats

Published on: March 24, 2020

Area of Science:

  • Neuroscience
  • Surgical Anatomy
  • Urology

Background:

  • Cauda equina syndrome (CES) arises from injury to lumbosacral nerve roots below the conus medullaris.
  • It occurs in 2-6% of laminectomies for lumbar disc herniation.
  • CES impacts neurological control of pelvic organs and lower extremities.

Purpose of the Study:

  • To elucidate the anatomical basis of CES.
  • To correlate nervous system anatomy with CES signs and symptoms.
  • To review current literature on the acute management of CES.

Main Methods:

  • Review of anatomical literature concerning the lumbosacral nerve roots.
  • Correlation of anatomical structures with clinical manifestations of CES.
  • Systematic literature search for acute management protocols.

Main Results:

  • Detailed anatomical description of the neural pathways governing bladder, rectal, anal, and sexual function.
  • Clear linkage between specific nerve root involvement and corresponding clinical deficits.
  • Identification of key elements in the acute management of CES.

Conclusions:

  • Understanding the neuroanatomy is crucial for diagnosing and managing CES.
  • Prompt recognition and management are vital for patient outcomes.
  • Further research into optimal acute treatment protocols is warranted.