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Coagulopathy in patients who experience snakebite.
Jae Seok Kim1, Jae Won Yang, Min Soo Kim
1Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
The Korean Journal of Internal Medicine
|July 24, 2008
Summary
Snakebite envenomation frequently causes coagulopathy. Rhabdomyolysis is a key risk factor for coagulopathy and disseminated intravascular coagulation (DIC) following snakebite, persisting for days.
Area of Science:
- Toxicology
- Hematology
- Clinical Medicine
Background:
- Coagulopathy is a frequent snakebite complication.
- Limited data exists on the clinical significance of snakebite-induced coagulopathy.
Purpose of the Study:
- To analyze the characteristics of coagulopathy after snakebite envenomation.
- To determine the clinical importance of coagulopathy in snakebite patients.
Main Methods:
- A case-control study involving 98 snakebite patients.
- Patients were classified using the ISTH DIC scoring system into normal, simple coagulopathy, and DIC groups.
- The coagulopathy group comprised both simple coagulopathy and DIC subgroups.
Main Results:
- Coagulopathy group showed decreased Hct, protein, albumin, ALP, and cholesterol.
- Leukocytosis and rhabdomyolysis were linked to coagulopathy; hemolysis and rhabdomyolysis to DIC.
- Rhabdomyolysis was a significant risk factor for coagulopathy, with effects lasting 6-7 days.
Conclusions:
- Identifying specific characteristics aids in managing snakebite-induced coagulopathy.
- Rhabdomyolysis is a critical indicator for coagulopathy and DIC in snakebite victims.
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