Related Experiment Video
Updated: Jul 3, 2026
Autonomously Bioluminescent Mammalian Cells for Continuous and Real-time Monitoring of Cytotoxicity
Published on: October 28, 2013
[A study on toxicity of aquaculture drugs to luminescent bacteria]
Jing Ma1, Changhua Shi, Shuying Wu
1MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
Objective:
To study the dose-response relation of the fish drugs and their joint toxicity on the luminescent bacteria.
Methods:
The single and joint toxicity of four kinds of fish drugs were inspected and evaluated by applying luminescent bacteria toxicity test. RESULTS; Four chemical componds were negatively correlated with luminescence and all correlation coefficient were greater than 0.99. From the dose response curve 50% effective concentration calculated for luminescent bacteria were 0.61 mg/L for Pb2+, 0.79 mg/L for Cu2+, 0.81 mg/L for furazolidone and 489.2 mg/L for chloramphenicol. K value of joint toxicity were 1.65 between Pb2+ and furazolidone, 1.09 between Pb2+ and chLoramphenicol and 1.58 between furazolidone and chloramphenicol.
Conclusion:
Pb2+, Cu2+, furazolidone and chLoramphenicol inhibited bacterial luminescence under certain concentration. Pb2+ and furazolidone, Pb2+ and chloramphenicol, furazolidone and chloramphenicol showed an addition effect to luminescent bacteria.
More Related Videos
09:29In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging
Published on: April 28, 2017
11:26Ecotoxicological Method with Marine Bacteria Vibrio anguillarum to Evaluate the Acute Toxicity of Environmental Contaminants
Published on: May 26, 2017
