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Updated: Jul 3, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
Professor Aristides Leão. Much more than spreading depression
Péricles Maranhão-Filho1, Maurice Vincent
1Department of Neurology, Universidade Federal do Ris de Janeiro, Rio de Janeiro, Brazil.
Abstract:
Professor Leão described cortical spreading depression (CSD) in 1944 and changed the way migraine pathophysiology is scientifically conceived. This Brazilian professor and researcher developed his career in Rio de Janeiro. Because of him, the city once became the CSD world capital, attracting scientists from many laboratories around the globe. Aristides Leão was first and foremost a naturalist, a man genuinely interested in birds, fishes, plants, shells, and neuroscience. He could easily fascinate whoever would come for a chat, leaving no question without answers. He was born in 1914 and died in 1993. This report focuses on his life, family, habits, and hobbies, describing a little of Leão apart from CSD and the year of 1944.
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