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Prevalence and genotype distribution of hepatitis C virus among apparently healthy individuals in Mongolia: a

Oidov Baatarkhuu1, Do Young Kim, Sang Hoon Ahn

  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Liver International : Official Journal of the International Association for the Study of the Liver
|July 24, 2008
PubMed

Insights

Hepatitis C virus (HCV) infection affects 11.0% of the apparently healthy Mongolian population, with genotype 1b being predominant. Urgent preventive and therapeutic strategies are needed for this HCV-endemic region.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health

Background:

  • Hepatitis C virus (HCV) is a significant cause of liver disease in Mongolia.
  • Nationwide prevalence data for HCV infection in Mongolia were previously unavailable.
  • HCV contributes to liver cirrhosis and hepatocellular carcinoma (HCC).

Purpose of the Study:

  • To determine the population-based prevalence of HCV infection in Mongolia.
  • To investigate the distribution of HCV genotypes nationwide.
  • To assess HCV infection in apparently healthy individuals.

Main Methods:

  • A two-stage cluster random sampling method was used.
  • Sera were collected from 1512 residents across Ulaanbaatar and 12 provinces.
  • Anti-HCV antibodies were tested, followed by HCV RNA detection and genotyping for positive samples.

Main Results:

  • The overall prevalence of anti-HCV antibodies was 15.6%, with 11.0% testing positive for HCV RNA.
  • Hepatitis C virus genotype 1b was predominant, found in 98.8% of cases.
  • HCV RNA prevalence increased with age, reaching 32.6% in individuals over 61 years old.

Conclusions:

  • Approximately 11.0% of the apparently healthy Mongolian population harbors detectable HCV RNA.
  • Hepatitis C virus genotype 1b is the most common strain in Mongolia.
  • There is an urgent need for preventive and therapeutic interventions for chronic hepatitis C in Mongolia.
Abstract

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